Post - doctoral position . Improving inference algorithms for macromolecular structure determination

نویسندگان

  • Frédéric Havet
  • Dorian Mazauric
چکیده

Biological phenomena are based on assemblies of bio-molecules, whose properties depend on structural and dynamic features of their subunits. Experimental studies of such systems face limitations, typically yielding high resolution models of subunits, or low resolution information for the whole assembly. This project focuses on combinatorial algorithms for the connectivity inference problem for mass spectrometry data, so as to discover the interfaces between subunits within an assembly.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

An Introduction to Inference and Learning in Bayesian Networks

Bayesian networks (BNs) are modern tools for modeling phenomena in dynamic and static systems and are used in different subjects such as disease diagnosis, weather forecasting, decision making and clustering. A BN is a graphical-probabilistic model which represents causal relations among random variables and consists of a directed acyclic graph and a set of conditional probabilities. Structure...

متن کامل

Sample size determination for logistic regression

The problem of sample size estimation is important in medical applications, especially in cases of expensive measurements of immune biomarkers. This paper describes the problem of logistic regression analysis with the sample size determination algorithms, namely the methods of univariate statistics, logistics regression, cross-validation and Bayesian inference. The authors, treating the regr...

متن کامل

Crystallography & NMR system: A new software suite for macromolecular structure determination.

A new software suite, called Crystallography & NMR System (CNS), has been developed for macromolecular structure determination by X-ray crystallography or solution nuclear magnetic resonance (NMR) spectroscopy. In contrast to existing structure-determination programs, the architecture of CNS is highly flexible, allowing for extension to other structure-determination methods, such as electron mi...

متن کامل

Probabilistic models and machine learning in structural bioinformatics.

Structural bioinformatics is concerned with the molecular structure of biomacromolecules on a genomic scale, using computational methods. Classic problems in structural bioinformatics include the prediction of protein and RNA structure from sequence, the design of artificial proteins or enzymes, and the automated analysis and comparison of biomacromolecules in atomic detail. The determination o...

متن کامل

Position Control of a Pulse Width Modulated Pneumatic Systems: an Experimental Comparison

In this study, a new adaptive controller is proposed for position control of pneumatic systems. Difficulties associated with the mathematical model of the system in addition to the instability caused by Pulse Width Modulation (PWM) in the learning-based controllers using gradient descent, motivate the development of a new approach for PWM pneumatics. In this study, two modified Feedback Error L...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2016